Genomics & Genetics Weekly
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Aortic Aneurysms
Reports outline aortic aneurysms research from Y.M. Ruigrok and colleagues
July 4th, 2008
"The 19q13.3 locus for intracranial aneurysms (IA) partly overlaps with the 19q13 locus for abdominal aortic aneurysms (AAA). A common genetic risk factor located in this locus for the two aneurysm types seems plausible," scientists writing in the Journal of Neurology Neurosurgery and Psychiatry report. "The transforming growth factor beta (TGF-beta) signalling pathway plays a role in aortic aneurysms but may also play a role in aneurysms in general. In the combined region of the 19q13 loci for IA and AAA we identified two candidate genes that are both involved in the TGF-beta signalling pathway: hepsin (HPN) and the latent transforming growth factor beta-binding...
Source: Genomics & Genetics Weekly (2008-07-04)
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