Genomics & Genetics Weekly
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Breast Cancer
New breast cancer study results reported from University of Leicester
July 4th, 2008
According to recent research published in the journal Breast Cancer Research and Treatment, "Indole-3-carbinol (I3C), a dietary chemopreventive compound, induces cell death in human breast cancer cells by modulating activities of Src and epidermal growth factor receptor (EGFR). The effect of I3C on NF-kappa B, constitutively activated in breast cancer cells, was investigated." "Nuclear extracts of MDA-MB-468, MDA-MB-231 and HBL100 cells contained all of the Rel proteins with similar expression patterns in the latter two. The level of NF-kappa B-regulated reporter gene expression was in the order HBL100 << MDA-MB-468 << MDA-MB-231. Upstream inhibition,...
Source: Genomics & Genetics Weekly (2008-07-04)
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