Genomics & Genetics Weekly
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Breast Cancer
Research from Leiden University in the area of breast cancer described
July 4th, 2008
"Loss of heterozygosity (LOH) at chromosome arm 16q is frequently observed in human breast cancer, suggesting that one or more target tumor suppressor genes (TSGs) are located there. However, detailed mapping of the smallest region of LOH has not yet resulted in the identification of a TSG at 16q," scientists in Leiden, Netherlands report. "Therefore, the present study attempted to identify TSGs using an approach based on mRNA expression. A cDNA microarray for the 16q region was constructed and analyzed using RNA samples from 39 breast tumors with known LOH status at 16q. Five genes were identified to show lower expression in tumors with LOH at 16q compared to tumors...
Source: Genomics & Genetics Weekly (2008-07-04)
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