Genomics & Genetics Weekly
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Cancer Gene Therapy
New cancer gene therapy data have been reported by researchers at University of Utrecht
July 4th, 2008
According to recent research published in the journal Molecular Pharmaceutics, "A series of cationic, methacrylamide polymers was tested for use as a biodegradable gene carrier in ovarian cancer. Tumor transfection activity of polyplexes consisting of a reporter gene and different methacrylamide polymers was assessed, after intraperitoneal injection in mice bearing an ovarian cancer xenograft." "In this model, polyplexes based on poly(HPMA-DMAE) showed transfection activity similar to polyplexes based on the nondegradable and rather toxic polyethylenimine (PEI22). The tumor transfection activity of the pHPMA-DMAE polyplexes was remarkable considering their poor...
Source: Genomics & Genetics Weekly (2008-07-04)
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