Genomics & Genetics Weekly
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Cancer
Studies conducted at S. Kumaraswamy et al on cancer recently published
July 4th, 2008
According to recent research published in the journal Cancer Research, "The microarray analysis of total cellular RNA is a common method used in the evaluation of radiation-induced gene expression. However, profiling the cellular transcriptome does not take into account posttranscriptional processes that affect gene expression." "To better define the genes whose expression is influenced by ionizing radiation, we used polysome-bound RNA to generate gene translation profiles for a series of tumor and normal cell lines. Cell lines were exposed to 2 Gy, polysome-bound RNA isolated 6 hours later, and then subjected to microarray analysis. To identify the genes whose...
Source: Genomics & Genetics Weekly (2008-07-04)
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