Genomics & Genetics Weekly
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Cystic Fibrosis
New cystic fibrosis data have been reported by scientists at University of North Carolina
July 4th, 2008
According to a study from the United States, "In cystic fibrosis (CF), the absence of functional CFTR leads to dysregulated Na+ absorption across airway epithelia. We established an in vitro model of dysregulated Na+ absorption by treating polarized normal human bronchial epithelial cells (HBEs) with nystatin (Nys), a polyene antibiotic that enables monovalent cations to permeate biological membranes." "Acute mucosal Nys produced a rapid increase in short circuit current (I-sc) that reflected increased transepithelial Na+ absorption and required Na+/K(+)ATPase activity. The acute increase in I-sc was associated with increased mucosal liquid absorption. Prolonged mucosal...
Source: Genomics & Genetics Weekly (2008-07-04)
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