Genomics & Genetics Weekly
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Cystic Fibrosis
Studies from Dartmouth College, Medical Department have provided new data on cystic fibrosis
July 4th, 2008
"P. aeniginosa forms biofilms in the lungs of individuals with cystic fibrosis (CF); however, there have been no effective model systems for studying biofilm formation in the CF lung. We have developed a tissue culture system for growth of P. aeruginosa biofilms on CF-derived human airway cells that promotes the formation of highly antibiotic-resistant microcolonies, which produce an extracellular polysaccharide matrix and require the known abiotic biofilm formation genes flgK and pilB. Treatment of P. aeruginosa biofilms with tobramycin reduced the virulence of the biofilms both by reducing bacterial numbers and by altering virulence gene expression," investigators in the United States...
Source: Genomics & Genetics Weekly (2008-07-04)
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