Genomics & Genetics Weekly
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DNA Libraries
Research conducted at D. Dirnberger and co-authors has provided new information about DNA libraries
July 4th, 2008
"The yeast split-ubiquitin system has previously been shown to be suitable to detect protein interactions of membrane proteins and of transcription factors in vivo. Therefore, this technology complements the classical split-transcription factor based yeast two-hybrid system (Y2H)," scientists writing in the journal Nucleic Acids Research report. "Success or failure of the Y2H depends primarily on the ability to avoid false-negative and false-positive hits that become a limiting factor for the value of the system, especially in large scale proteomic analyses. We provide here a systematic assessment of parameters to help improving the quality of split-ubiquitin...
Source: Genomics & Genetics Weekly (2008-07-04)
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