Genomics & Genetics Weekly
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DNA Research
New DNA research study findings recently were reported by researchers at National Institutes of Health
July 4th, 2008
"Base excision repair (BER) provides relief from many DNA lesions. While BER enzymes have been characterized biochemically, BER functions within cells are much less understood, in part because replication bypass and double-strand break (DSB) repair can also impact resistance to base damage," researchers in the United States report. "To investigate BER in vivo, we examined the repair of methyl methanesulfonate (MMS) induced DNA damage in haploid G1 yeast cells, so that replication bypass and recombinational DSB repair cannot occur. Based on the heat-lability of MMS-induced base damage, an assay was developed that monitors secondary breaks in full-length yeast chromosomes...
Source: Genomics & Genetics Weekly (2008-07-04)
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