Genomics & Genetics Weekly
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DNA Research
Research from Creighton University has provided new information about DNA research
July 4th, 2008
According to recent research published in the journal Nucleic Acids Research, "Antigen receptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination. This process proceeds through two distinct phases: a cleavage phase in which the RAG1 and RAG2 proteins introduce DNA double-strand breaks at antigen receptor gene segments, and a joining phase in which the resulting DNA breaks are processed and repaired via the non-homologous end-joining (NHEJ) repair pathway." "Genetic and biochemical evidence suggest that the RAG proteins play an active role in guiding the repair of DNA breaks introduced during V(D)J recombination to the...
Source: Genomics & Genetics Weekly (2008-07-04)
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