Genomics & Genetics Weekly
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Cystic Fibrosis
Reports outline cystic fibrosis research from University of Cincinnati
July 4th, 2008
According to a study from the United States, "Patients suffering from cystic fibrosis (CF) commonly harbor the important pathogen Pseudomonas aeruginosa in their airways. During chronic late-stage CF, P. aeruginosa is known to grow under reduced oxygen tension and is even capable of respiring anaerobically within the thickened airway mucus, at a pH of similar to 6.5." "Therefore, proteins involved in anaerobic metabolism represent potentially important targets for therapeutic intervention. In this study, the clinically relevant ''anaerobiome'' or ''proteogenome'' of P. aeruginosa was assessed. First, two different proteomic approaches were used to identify proteins...
Source: Genomics & Genetics Weekly (2008-07-04)
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