Genomics & Genetics Weekly
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DNA Research
Studies conducted at Yale University on DNA research recently published
July 4th, 2008
"The type IA topoisomerases have been implicated in the repair of dsDNA breaks by homologous recombination and in the resolution of stalled or damaged DNA replication forks; thus, these proteins play important roles in the maintenance of genomic stability. We studied the functions of one of the two mammalian type IA enzymes, Top3 beta, using murine embryonic fibroblasts (MEFs) derived from top3 beta(-/-) embryos. top3 beta(-/-) MEFs proliferated more slowly than TOP3 beta(+/+) control MEFs, demonstrated increased sensitivity to DNA-damaging agents such as ionizing and UV radiation, and had increased DNA double-strand breaks as manifested by increased gamma-H2-AX phosphorylation,"...
Source: Genomics & Genetics Weekly (2008-07-04)
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