Genomics & Genetics Weekly
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DNA Research
Studies from D.J. Richard et al in the area of DNA research described
July 4th, 2008
"Single- strand DNA ( ssDNA)- binding proteins ( SSBs) are ubiquitous and essential for a wide variety of DNA metabolic processes, including DNA replication, recombination, DNA damage detection and repair(1). SSBs have multiple roles in binding and sequestering ssDNA, detecting DNA damage, stimulating nucleases, helicases and strand- exchange proteins, activating transcription and mediating protein - protein interactions," investigators in Brisbane, Australia report. "In eukaryotes, the major SSB, replication protein A ( RPA), is a heterotrimer(1). Here we describe a second human SSB ( hSSB1), with a domain organization closer to the archaeal SSB than to RPA. Ataxia...
Source: Genomics & Genetics Weekly (2008-07-04)
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