Genomics & Genetics Weekly
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Drug Resistance
New findings reported from Wake Forest University, Medical Department describe advances in drug resistance
July 4th, 2008
"A major component of the anticarcinogenic activity of the dietary chemopreventive agent sulforaphane (SFN) is attributed to its ability to induce expression of phase II detoxification genes containing the antioxidant response element (ARE) within their promoters. Because SFN is a reactive electrophile--readily forming conjugates with glutathione (GSH)--we asked whether expression of glutathione S-transferase (GST) P1-1 and the GSH conjugate efflux pump, multidrug resistance or resistance-associated protein (MRP) 1, would significantly modify the cellular response to SFN exposure," researchers in the United States report. "This was investigated using GST- and MRP1-poor...
Source: Genomics & Genetics Weekly (2008-07-04)
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