Genomics & Genetics Weekly
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Epidermolysis Bullosa
Reports from Thomas Jefferson University add new data to research in epidermolysis bullosa
July 4th, 2008
According to recent research from the United States, "Junctional epidermolysis bullosa (JEB) is an inherited mechanobullous disease characterized by reduced adherence of the epidermal keratinocytes to the underlying dermis, and is often caused by the absence of functional laminin 332 due to the lack or dysfunction of its beta 3 chain. As there are no specific therapies for JEB, we tested whether a protein replacement strategy could be applicable for the restoration of the laminin 332 assembly and reversion of the JEB phenotype in human keratinocytes that lack beta 3 subunit." "Here, we developed the protocol for production and purification of the biologically active...
Source: Genomics & Genetics Weekly (2008-07-04)
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