Genomics & Genetics Weekly
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Gene Therapy
Reports on gene therapy findings from Swansea University provide new insights
July 4th, 2008
"One of the most useful tools for investigating the aetiopathology of cancer is the mutation spectrum, which comprises the type and distribution of mutations within a gene sequence. Many studies have generated mutagen-induced spectra using in vitro or in vivo model systems in an attempt to find correlations with those observed in cancer-associated genes such as the TP53 tumour suppressor gene," researchers in Wales report. "Consequently, meaningful similarities in the types of mutation found in induced and human spectra have been demonstrated. However, it is more difficult to draw such conclusions about the distribution or sequence context of mutations when they arise...
Source: Genomics & Genetics Weekly (2008-07-04)
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