Genomics & Genetics Weekly
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Gene Therapy
Reports summarize gene therapy research from Aachen University
July 4th, 2008
According to recent research from Aachen, Germany, "The MYC/MAX/MAD network of transcriptional regulators controls distinct aspects of cell physiology, including cell proliferation and apoptosis. Within the network MAD proteins antagonize the functions of MYC oncoproteins, and the latter are deregulated in the majority of human cancers." "While MYC sensitizes cells to proapoptotic signals, the transcriptional repressor MAD1 inhibits apoptosis in response to a broad range of stimuli, including oncoproteins. The molecular targets of MAD1 that mediate inhibition of apoptosis are not known. Here we describe the phosphatase and tensin homologue deleted on chromosome ten...
Source: Genomics & Genetics Weekly (2008-07-04)
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