Genomics & Genetics Weekly
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Gene Therapy
Scientists at Wadsworth Center release new data on gene therapy
July 4th, 2008
According to a study from the United States, "Prevention of abnormal misfolding and aggregation of alpha synuclein (syn) protein in vulnerable neurons should be viable therapeutic strategies for reducing pathogenesis in Parkinson's disease. The nonamyloid component (NAC) region of alpha-syn shows strong tendencies to form beta-sheet structures, and deletion of this region has been shown to reduce aggregation and toxicity in vitro and in vivo." "The binding of a molecular species to this region may mimic the effects of such deletions. Single-chain variable fragment (ScFv) antibodies retain the binding specificity of antibodies and, when genetically manipulated to create...
Source: Genomics & Genetics Weekly (2008-07-04)
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