Genomics & Genetics Weekly
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Gene Therapy
Studies from M. Achour et al add new findings in the area of gene therapy
July 4th, 2008
"Inverted CCAAT box-binding protein of 90 kDa (ICBP90) is over-expressed in several types of cancer, including breast, prostate and lung cancers. In search for proteins that interact with the set and ring-associated (SRA) domain of ICBP90, we used the two-hybrid system and screened a placental cDNA library," scientists in Illkirch-Graffenstaden, France report. "Several clones coding for a new domain of DNMT1 were found. The interaction, between the ICBP90 SRA domain and the DNMT1 domain, has been confirmed with purified proteins by glutathione-S-transferase pull-down experiments. We checked whether ICBP90 and DNMT1 are present in the same macromolecular complexes in...
Source: Genomics & Genetics Weekly (2008-07-04)
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