Genomics & Genetics Weekly
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Genetics & Genomics
Recent findings from RIKEN highlight research in genetics & genomics
July 4th, 2008
"Lumbar-disc herniation (LDH), one of the most common musculoskeletal diseases, has strong genetic determinants. Recently, several genes that encode extracellular matrix (ECM) proteins in the intervertebral disc have been reported to associate with LDH," scientists in Tokyo, Japan report. "Thrombospondins (THBSs) I and 2 are good candidates for the LDH susceptibility gene: They are intervertebral disc ECM proteins that regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Here, we report that THBS2 is associated with LDH in Japanese populations. An intronic SNP in THBS2 (IVS10-8C -> T; rs9406328) showed...
Source: Genomics & Genetics Weekly (2008-07-04)
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