Genomics & Genetics Weekly
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Gene Therapy
Research on gene therapy discussed by N.J.P. Wierckx and co-researchers
July 4th, 2008
"The unknown genetic basis for improved phenol production by a recombinant Pseudomonas putida S12 derivative bearing the tpl (tyrosine-phenol lyase) gene was investigated via comparative transcriptomics, nucleotide sequence analysis, and targeted gene disruption. We show upregulation of tyrosine biosynthetic genes and possibly decreased biosynthesis of tryptophan caused by a mutation in the trpE gene as the genetic basis for the enhanced phenol production," scientists writing in the Journal of Bacteriology report. "In addition, several genes in degradation routes connected to the tyrosine biosynthetic pathway were upregulated. This either may be a side effect...
Source: Genomics & Genetics Weekly (2008-07-04)
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