Genomics & Genetics Weekly
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Genetics & Genomics
Research conducted at L.H. Jensen and co-researchers has updated our knowledge about genetics & genomics
July 4th, 2008
" Deficiency of DNA mismatch repair (MMR) causes microsatellite instability (MSI) in a subset of colorectal cancers. Patients with these tumours have a better prognosis and may have an altered response to chemotherapy," scientists in Vejle, Denmark report. "Some of the tumours are caused by hereditary mutations (hereditary nonpolyposis colon cancer or Lynch syndrome), but most are epigenetic changes of sporadic origin. The aim of this study was to define a robust and inexpensive strategy for such classification in clinical practice. Tumours and blood samples from 262 successive patients with colorectal adenocarcinomas were collected. Expression of the MMR proteins...
Source: Genomics & Genetics Weekly (2008-07-04)
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