DNA Research
Studies from University of Cambridge describe new findings in DNA research
Published in Genomics and Genetics Weekly, November 7th, 2008
According to a study from Cambridge, the United Kingdom, "DNA double- strand breaks ( DSBs) are repaired by two principal mechanisms: non- homologous end- joining ( NHEJ) and homologous recombination ( HR)(1). HR is the most accurate DSB repair mechanism but is generally restricted to the S and G2 phases of the cell cycle, when DNA has been replicated and a sister chromatid is available as a repair template(2-5)."
"By contrast, NHEJ operates throughout the cell cycle but assumes most importance in G1 ( refs 4, 6). The choice between repair pathways is governed by cyclindependent protein kinases (CDKs)(2,3,5,7), with a major site of control being at the level of DSB...
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