Genomics & Genetics Weekly
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Arthritis
Researchers from Tokushima Bunri University publish new studies and findings in the area of arthritis
December 12th, 2008
"While inflammatory cytokines are well-recognized critical factors for the induction of cyclooxygenase-2 (COX-2) in activated fibroblast-like synovial cells, the roles of biologically active components other than inflammatory cytokines in synovial fluid remain unknown. Herein, we assessed the role of lysophosphatidic acid (LPA), a pleiotropic lipid mediator, in COX-2 induction using synovial fluid of patients with rheumatoid arthritis (RA) in fibroblast-like RA synovial cells," scientists writing in the Journal of Immunology report. "Synovial fluid from RA patients stimulated COX-2 induction, which was associated with prostaglandin E, production, in RA synovial...
Source: Genomics & Genetics Weekly (2008-12-12)
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