Genomics & Genetics Weekly
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Asthma
New asthma research from Soonchunhyang University described
December 12th, 2008
" Aspirin-intolerant asthma (AIA) refers to the development of bronchoconstriction in asthmatic individuals following the ingestion of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). Angiotensin I-converting enzyme (ACE), a membrane-bound peptidase present in the lung, plays a pivotal role in the metabolism of the endogenous peptides involved in the pathogenesis of asthma," scientists writing in the journal Clinical and Experimental Allergy report. " We screened a Korean asthma cohort (581 asthmatics including 81 aspirin-intolerant asthmatics and 231 aspirin-tolerant asthmatics, and 181 normal controls) for four single nucleotide polymorphisms...
Source: Genomics & Genetics Weekly (2008-12-12)
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