Genomics & Genetics Weekly
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Atherosclerosis
New atherosclerosis research has been reported by scientists at Brigham and Women's Hospital
December 12th, 2008
According to recent research from the United States, "Rho kinases (ROCKS) are serine-threonine protein kinases that regulate the actin cytoskeleton. Recent studies suggest that ROCKs also play an important role in cardiovascular disease." "However, the isoform- and tissue-specific role of ROCKS in mediating this process is unknown. Using homologous recombination, we generated mutant mice harboring alleles with homozygous deletion of ROCK1 (ROCK1(-/-)). Most ROCK1(-/-) mice die perinatally. However, a few ROCK1(-/-) mice survive to adulthood, are phenotypically normal, and have no apparent compensatory changes in ROCK2. Using these ROCK1(-/-) mice, we show that ROCK1 in...
Source: Genomics & Genetics Weekly (2008-12-12)
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