Genomics & Genetics Weekly
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Atherosclerosis
Research from Q.J. Zhang et al broadens understanding of atherosclerosis
December 12th, 2008
According to a study from Beijing, People's Republic of China, " Hazardous environmental and genetic factors can damage endothelial cells to induce atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 may promote cell survival via novel antioxidative mechanisms." "The current study tested the hypothesis that SIRT1, specifically overexpressed in the endothelium, is atheroprotective. Methods and results Human umbilical vein endothelial cells (HUVECs) were used to study the effects of oxidized low-density lipoprotein (LDL) on SIRT1 expression. Endothelial cell-specific SIRT1 transgenic (SIRT1-Tg) mice were used to study the effects of...
Source: Genomics & Genetics Weekly (2008-12-12)
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