Genomics & Genetics Weekly
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Breast Cancer
Findings in breast cancer reported from K.P.M. Suijkerbuijk and co-researchers
December 12th, 2008
"Promoter methylation is a common epigenetic mechanism to silence tumor suppressor genes during breast cancer development. We investigated whether BRCA1-associated breast tumors show cancer-predictive methylation patterns similar to those found in sporadic tumors," investigators in Netherlands report. "Quantitative multiplex methylation-specific PCR of 11 genes involved in breast carcinogenesis (RARB, RASSF1, TWIST1, CCND2, ESR1, SCGB3A1, BRCA1, BRCA2, CDKN2A, APC, CDH1) was carried out on 32 BRCA1-associated and 46 sporadic breast carcinomas and on normal breast tissue from seven BRCA1 mutation carriers and 13 non-carriers. The extent of cumulative methylation...
Source: Genomics & Genetics Weekly (2008-12-12)
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