Genomics & Genetics Weekly
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Breast Cancer
Research conducted at B.J. Metge and co-authors has provided new information about breast cancer
December 12th, 2008
According to recent research from the United States, "Breast Cancer Metastasis Suppressor 1 (BRMS1) suppresses metastasis of human breast cancer, ovarian cancer and melanoma in athymic mice. Studies have also shown that BRMS1 is significantly downregulated in some breast tumors, especially in metastatic disease." "However, the mechanisms which regulate BRMS1 expression are currently unknown. Upon examination of the BRMS1 promoter region by methylation specific PCR (MSP) analysis, we discovered a CpG island (-3477 to -2214), which was found to be hypermethylated across breast cancer cell lines. A panel of 20 patient samples analyzed showed that 45% of the primary tumors...
Source: Genomics & Genetics Weekly (2008-12-12)
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