Genomics & Genetics Weekly
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Cancer
Research from D.S. Cross et al has provided new information about cancer
December 12th, 2008
"Homeobox (HOX) genes are crucial regulators of cell growth and differentiation. These genes initiate and control gene expression cascades that drive development," scientists in the United States report. "More recently, the absent or aberrant expression of HOX genes has been implicated in cancer development. Despite the observance of these expression changes, the regulation of the HOX genes in adult tissues and how these genes become deregulated in cancerous tissues still needs much investigation. We characterized the promoter region of the HOXB13 gene. A 3 kb region upstream of the HOXB13 gene, which included the 5'UTR, increased reporter gene expression in LNCaP cells...
Source: Genomics & Genetics Weekly (2008-12-12)
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