Genomics & Genetics Weekly
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Cancer Gene Therapy
Scientists at INSERM publish new data on cancer gene therapy
December 12th, 2008
According to recent research published in the journal Human Gene Therapy, "The hepatocarcinoma-intestine-pancreas (HIP) gene, also called pancreatitis-associated protein-1 (PAP1) or Reg III alpha, is activated in most human hepatocellular carcinomas (HCCs) but not in normal liver, which suggests that HIP regulatory sequence Could be used as efficient liver tumor-specific promoters to express a therapeutic polynucleotid in liver cancer. The sodium iodide symporter (NIS), which has recognized therapeutic and reporter gene properties, is appropriate to evaluate the transcriptional strength and specificity of the HIP promoter in HCC." "For this purpose, we...
Source: Genomics & Genetics Weekly (2008-12-12)
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