Genomics & Genetics Weekly
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Celiac Disease
Research reports on celiac disease from K.M. Harris and colleagues provide new insights
December 12th, 2008
"IL-23 has been implicated in the pathogenesis of several tissue-specific autoimmune I diseases. Currently, celiac disease (CD) is the only autoimmune disease in which both the major genetic (95% HLA-DQ2(+)) and etiologic factors (dietary glutens) for susceptibility are known," researchers in the United States report. "We demonstrate that wheat gliadin induces significantly greater production of IL-23, IL-1 beta, and TNF-alpha in PBMC from CD patients compared with HLA-DQ2(+) healthy controls, strongly advocating a role for IL-23 in the pathogenesis of CD. Moreover, IL-1 beta alone triggered IL-23 secretion and the IL-IR antagonist inhibited this response in PBMC and...
Source: Genomics & Genetics Weekly (2008-12-12)
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