Genomics & Genetics Weekly
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Celiac Disease
Study results from University of Copenhagen in the area of celiac disease published
December 12th, 2008
"Activation of small intestinal gluten-reactive CD4(+) stop T-cells is a critical event in celiac disease. Deamidation of specific glutamine residues by tissue transglutaminase enhances the binding of T-cell activating gliadin epitopes to DQ2, increasing T-cell recognition," scientists in Copenhagen, Denmark report. "Our purpose was to investigate whether deamidated gliadin epitopes can be generated in the small intestinal mucosa by tissue transglutaminase and to characterize the location of the process. Intestinal explants from pig intestine and frozen biopsy slices from human and rat intestine were incubated with alpha-gliadin peptides containing the immunodominant...
Source: Genomics & Genetics Weekly (2008-12-12)
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