Genomics & Genetics Weekly
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Cleft Lip
Reports outline cleft lip study findings from National Institutes of Health
December 12th, 2008
"Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folate-related genes associated with clefts have, however, often been inconclusive," investigators in the United States report. "This study examined four SNPS related to folate metabolism (MTHFR 677 C -> T, MTHFR 1298 A -> C, MTHFD1 1958 G -> A, and TC II 776 C -> G) in a large Irish population to clarify their relationship with clefts. Cases and their parents were recruited from major surgical centers performing cleft repairs in Ireland and a support organization. Data on risk factors,...
Source: Genomics & Genetics Weekly (2008-12-12)
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