Genomics & Genetics Weekly
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Cystic Fibrosis
Research results from University of California update understanding of cystic fibrosis
December 12th, 2008
"The roles of the Pseudomonas aeruginosa-derived pigment pyocyanin (PYO) as an oxidant and activator of the proinflammatory transcription factor NF-kappa B were tested in a cystic fibrosis (CF) airway epithelial cell line, CF15.100 mc M PYO on its own had no effect or only small effects to activate NF-kappa B (< 1.5-fold), but PYO synergized with the TLR5 agonist flagellin. Flagellin activated NF-kappa B 4-20-fold, and PYO increased these activations > 2.5- fold," scientists in the United States report. "PYO could have synergized with flagellin to activate NF-kappa B by redox cycling with NADPH, generating superoxide (O-2(.-).), hydrogen peroxide (H2O2), and...
Source: Genomics & Genetics Weekly (2008-12-12)
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