Genomics & Genetics Weekly
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Cystic Fibrosis
Researchers from University of California publish findings in cystic fibrosis
December 12th, 2008
According to recent research published in the Journal of Medicinal Chemistry, "N-(5-(2-(5-Chloro-2-methoxyphenylamino)thiazol-4-yl)-4-methylthiazol-2-yl)pivalamide 1 (compound 15jf) was found previously to correct defective cellular processing of the cystic fibrosis protein Delta F508-CFTR. Eight C4'-C5 C,C-bond-controlling bithiazole analogues of 1 were designed, synthesized, and evaluated to establish that constraining rotation about the bithiazole-tethering has a significant effect on corrector activity." "For example, constraining the C4'-C5 bithiazole tether in the s-cis conformation...
Source: Genomics & Genetics Weekly (2008-12-12)
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