Genomics & Genetics Weekly
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Diabetes
Data on diabetes described by researchers at National Institute of Diabetes and Digestive and Kidney Disease
December 12th, 2008
According to a study from the United States, "The human olfactomedin 4 gene (OLFM4, also known as hGC-1, GW112) is thought to be a useful marker for early myeloid development. To understand the molecular mechanisms underlying granulocyte colony-stimulating factor (G-CSF)-stimulated OLFM4 expression, we characterized the promoter region of OLFM4." "The 35-bp region (-101 to -66) of the proximal promoter regulated reporter gene expression, and mutation of the nuclear factor (NF)-kappa B binding site within the promoter abolished the binding of the transcription factor and the ability to regulate OLFM4 expression. G-CSF increased reactive oxygen species (ROS) production in...
Source: Genomics & Genetics Weekly (2008-12-12)
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