Genomics & Genetics Weekly
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Dialysis
Studies from S. Schmidt and co-researchers yield new data on dialysis
December 12th, 2008
"Nitric oxide (NO) is known to be an important mediator of macrophage cytotoxicity. NO in macrophages is generated via the inducible nitric oxide synthases (iNOS)," scientists in Berlin, Germany report. "Macrophage dysfunction is an important contributory factor for the increased incidence of infections in uraemia. Recently, we identified phenylacetic acid (PAA) as a novel uraemic toxin in patients on regular haemodialysis. PAA inhibits iNOS expression. In the present study, we investigated the impact of PAA on macrophage function. RAW 264.7 cells were stimulated by LPS/ IFN-gamma in the absence and presence of PAA. iNOS mRNA was determined by real-time PCR, iNOS...
Source: Genomics & Genetics Weekly (2008-12-12)
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