Genomics & Genetics Weekly
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Enzyme Research
New enzyme research study results reported from V.G. Deyebenes et al
December 12th, 2008
According to recent research from Madrid, Spain, "Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates." "As a bystander effect, endogenous AID levels can also promote the generation of chromosome translocations, suggesting that the fine tuning of AID expression may be critical to restrict B cell lymphomagenesis. To...
Source: Genomics & Genetics Weekly (2008-12-12)
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