Genomics & Genetics Weekly
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Enzyme Research
Study data from University of Saarland update understanding of enzyme research
December 12th, 2008
"Pharmacophore modeling of a series of aldosterone synthase (CYP11B2) inhibitors triggered the design of compounds 11 and 12 by extending a previously established naphthalene molecular scaffold (e.g., present in molecules 1 and 2) via introduction of a phenyl or benzyl residue in 3-position. These additional aromatic moieties have been hypothesized to fit into the newly identified hydrophobic pharmacophore feature HY3," scientists writing in the Journal of Medicinal Chemistry report. "Subsequent docking studies in our refined CYP11B2 protein model have been performed prior to synthesis to estimate the inhibitory properties of the proposed molecules. While...
Source: Genomics & Genetics Weekly (2008-12-12)
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