Genomics & Genetics Weekly
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Gene Therapy
Genome Center reports research in gene therapy
December 12th, 2008
" Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout," scientists in London, the United Kingdom report. "The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. We investigated whether SLC2A9 is a functional urate transporter that contributes to the...
Source: Genomics & Genetics Weekly (2008-12-12)
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