Genomics & Genetics Weekly
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Gene Therapy
New gene therapy study findings have been reported by scientists at National Institutes of Health
December 12th, 2008
"Immunoglobulin (Ig) isotype switching is a recombination event that changes the constant domain of antibody genes and is catalyzed by activation-induced cytidine deaminase (AID). Upon recruitment to Ig genes, AID deaminates cytidines at switch (S) recombination sites, leading to the formation of DNA breaks," researchers in the United States report. "In addition to their role in isotype switching, AID-induced lesions promote Igh-cMyc chromosomal translocations and tumor development. However, cMyc translocations are also present in lymphocytes from healthy humans and mice, and thus, it remains unclear whether AID directly contributes to the dynamics of B cell...
Source: Genomics & Genetics Weekly (2008-12-12)
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