Genomics & Genetics Weekly
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Gene Therapy
Report summarizes gene therapy study findings from University College
December 12th, 2008
"Recent evidence has suggested that the tumor-suppressor gene p53 has a role in regulating antioxidant response in cancer cells. This study was conducted to determine whether p53 regulates redox enzymes in a neuronal context in RGCs and whether this regulation contributes to an increased survival signal," scientists in Cork, Ireland report. "The expression of p53, and its putative responsive antioxidant enzymes sestrin 2, catalase, Cu/ZnSOD, and MnSOD were evaluated in the developing rat retina by immunohistochemistry and Western blot. Small interfering (si) RNA to p53 was used in an RGC cell line, RGC-5, and downstream effects on antioxidants observed by Western blot....
Source: Genomics & Genetics Weekly (2008-12-12)
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