Genomics & Genetics Weekly
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Alzheimer Disease
Data on Alzheimer disease published by D.A. Bennett and colleagues
June 19th, 2009
According to a study from the United States, "The identification of susceptibility alleles to risk of Alzheimer disease (AD) is a major public health priority. Using apolipoprotein E genotype (APOE), we examined whether neuropathologic intermediate phenotypes, the pathology underlying clinical AD that presumably lies intermediate in the causal chain, would increase power for genetic associations." "More than 700 older persons underwent annual evaluation and organ donation as part of the Religious Orders Study or Rush Memory and Aging Project. A total of 536 autopsied persons with clinical AD or without dementia with APOE genotyping and a quantitative measure of AD...
Source: Genomics & Genetics Weekly (2009-06-19)
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