Genomics & Genetics Weekly
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Antibody Libraries
Reports from Osaka University describe recent advances in antibody libraries
June 19th, 2009
"Phage antibody library is a promising tool for rapidly creating in vitro single-chain Fv (scFv) antibodies to various antigens. The scFv can also act like a subcellularly-expressed antibody, known as intrabody, and can either be used as a novel research tool or used efficiently for targeted molecular therapy," investigators in Osaka, Japan report. "However, there are only a few existing reports about the successful expression of scFvs as functional antibodies in the cell, mainly because poor quality scFv phage antibody libraries were used to isolate the intrabody clones. The aim of this study was to isolate intrabody-forming scFv clones from the non-immune scFv phage...
Source: Genomics & Genetics Weekly (2009-06-19)
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