Genomics & Genetics Weekly
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RNA Research
Research reports on RNA research from F.C. Tang and colleagues provide new insights
July 10th, 2009
According to recent research from the United States, "Next-generation sequencing technology is a powerful tool for transcriptome analysis. However, under certain conditions, only a small amount of material is available, which requires more sensitive techniques that can preferably be used at the single-cell level." "Here we describe a single-cell digital gene expression profiling assay. Using our mRNA-Seq assay with only a single mouse blastomere, we detected the expression of 75% ( 5,270) more genes than microarray techniques and identified 1,753 previously unknown splice junctions called by at least 5 reads. Moreover, 8-19% of the genes with multiple known transcript...
Source: Genomics & Genetics Weekly (2009-07-10)
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