Genomics & Genetics Weekly
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Anthrax
Researchers' work from USA Scientific focuses on anthrax
July 10th, 2009
"The modulation of cellular processes by small molecule inhibitors, gene inactivation, or targeted knockdown strategies combined with phenotypic screens are powerful approaches to delineate complex cellular pathways and to identify key players involved in disease pathogenesis. Using chemical genetic screening, we tested a library of known phosphatase inhibitors and identified several compounds that protected Bacillus anthracis infected macrophages from cell death," scientists in the United States report. "The most potent compound was assayed against a panel of sixteen different phosphatases of which CD45 was found to be most sensitive to inhibition. Testing of a known...
Source: Genomics & Genetics Weekly (2009-07-10)
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