HIV/AIDS Immunology
Research on HIV/AIDS immunology detailed by scientists at King's College, Department of Infectious Diseases
Published in Genomics and Genetics Weekly, March 26th, 2010
Investigators publish new data in the report 'Matrix mediates the functional link between human immunodeficiency virus type 1 RNA nuclear export elements and the assembly competency of Gag in murine cells.' "Human immunodeficiency virus type 1 (HIV-1) assembles poorly in murine cells, reflecting inefficient targeting of the Gag structural polyprotein to the plasma membrane. Virus particle production can be restored by replacing the cis-acting Rev response element (RRE) in Gag-Pol mRNAs with multiple copies of the CTE (4xCTE), suggesting a mechanistic link between HIV-1 RNA trafficking and productive Gag assembly," investigators in London, the United Kingdom report.
"In...
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