Life Sciences

Investigators at University of Pennsylvania, Department of Biology zero in on life sciences

Published in Genomics and Genetics Weekly, May 7th, 2010

New research, 'Coordination of Rab8 and Rab11 in primary ciliogenesis,' is the subject of a report. "Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease," investigators in the United States report.

"Recent studies have demonstrated that polarized vesicular transport involving Rab8 and its guanine nucleotide-exchange factor Rabin8 is essential for primary ciliogenesis. Here we report that Rabin8 is a direct downstream effector of Rab11, which functions in membrane trafficking from...

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Source: Genomics and Genetics Weekly (2010-05-07)

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