Alzheimer Disease
Data on Alzheimer disease detailed by W.C. Leon and co-authors
Published in Genomics and Genetics Weekly, June 11th, 2010
"Alzheimer's disease (AD) is a neurodegenerative pathology in which amyloid-beta (A beta) peptide accumulates in different brain areas leading to deposition of plaques and a progressive decline of cognitive functions. After a decade in which a number of transgenic (Tg) mouse models mimicking AD-like amyloid-deposition pathology have been successfully generated, few rat models have been reported that develop intracellular and extracellular A beta accumulation, together with impairment of cognition," scientists in Montreal, Canada report.
"The generation of a Tg rat reproducing the full AD-like amyloid pathology has been elusive. Here we describe the generation and...
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